Research for Chronic Kidney Disease
There’s currently no treatment for chronic kidney disease caused by variations in the APOL1 gene – but we’re researching to learn more about that.
SEE IF YOU QUALIFY
Please answer the questions in the form below to see if you meet the basic study requirements. It should take about 10 minutes of your time.
We respect your privacy. Please read and agree to the following privacy statement before completing the questionnaire:
Your answers to the questionnaire will be recorded, but your information will be kept confidential and used only for the purposes of this study. This clinical research study welcomes all people who meet the criteria, regardless of sex, gender, sexual orientation, race, or religion.
If you are a patient, this page contains a contact form and some pre-screening questions to determine whether you may be eligible to take part in the clinical research study. By answering the following pre-screening questions, you agree to provide your information to 1nHealth, a service provider of the sponsor of this study, Vertex Pharmaceuticals Incorporated (“Vertex”). The categories of information collected via this questionnaire include information such as your name and contact information, as well as information about your health, lifestyle and family history (to determine your potential eligibility). Your information will be used only to determine whether you are eligible for this research study. Please only fill out this form if you are 18 years old or older.
The information you submit online will not be shared with Vertex in any way that could identify you. 1nHealth, which is located in the United States, will store this information as the operator of the website and will only share information in aggregate with Vertex. If your answers to the questionnaire indicate that you may be eligible for the study, you will have the option (with your permission) to be connected with a research site in your area who will conduct a full pre-screening.
We will store any information you provide through this website for as long as necessary to fulfill the purposes listed above, in accordance with applicable laws. You may withdraw your consent at any time and upon withdrawal of your consent we will delete your personal information within 48 hours.
For a fuller description of Vertex’s privacy practices and of your privacy rights if you are a California resident, please see Vertex’s privacy policy. If you have a question or want to exercise your privacy rights detailed in the above privacy policy, please contact info@1nhealth.com as Vertex will not receive your identifiable information. If you apply to learn about any other of 1nHealth’s studies, Vertex is not responsible for your data.
If you wish to have your information deleted within 48 hours, click here.
WHY PARTICIPATE?
Deciding to take part in a clinical research study is your decision. You can take as much time as you need to share any of the clinical research study information with family, friends, and your doctor, so that you can discuss your options and feel supported with your decision. If you qualify and participate, you may:
Get no-cost, investigational genetic testing to see if your chronic kidney disease is genetic
Get an investigational treatment, or a placebo, for chronic kidney disease
Have the possibility to receive compensation for study-related time and reimbursement for travel
WHAT'S INVOLVED?
First, fill out the form above.
Next, you may have some tests, including investigational genetic testing, to make sure you qualify.
If eligible, you may participate for up to 4 years. You can withdraw your participation at any time during the study.
FREQUENTLY ASKED QUESTIONS
The investigational treatment, VX-147, is an oral medication that’s being researched to evaluate how it works and if it prevents and/or delays end stage chronic kidney disease in people with the APOL1 gene variations.
No, not everyone will get the investigational treatment. 1 out of 2 participants will get the investigational treatment.
No, there is no cost to participate. Compensation for study-related time and reimbursement for study-related travel expenses may be available.
- APOL1-mediated kidney disease is caused by a substance in the body called the APOL1 protein.
- We all have the APOL1 protein in our bodies; however, some people have differences in their DNA (the genetic material in our body that carries information about how our body works) that means they carry a modified type of APOL1 protein, known as a variant.
- People with APOL1 variants are at a higher risk for chronic kidney disease, but it is still not known how the variants causes kidney disease.
- Several thousand years ago, APOL1 variant genes evolved in people who lived in Western and Central Africa, to protect them from a parasitic disease known as African sleeping sickness.
- This means that variants of APOL1 are more likely to occur in people of African descent, including people who identify as African American, Black, Caribbean, Sub-Saharan African, and Latino (Cuban, Mexican, Puerto Rican, or South or Central American).
Yes, you can withdraw your participation at any time during the study.
